Abstract
The purpose of this study was to quantify the clearance of amyloid-β (Aβ) protein by auditory stimulation in a mouse model of Alzheimer's disease (AD). Accumulation of Aβ is thought to be one of the causes of AD. It has been confirmed that Aβ in 5XFAD mice, a mouse model of AD, is reduced by auditory stimulation at a period of 40 Hz, in which sounds are switched on and off 40 times per second. A previous study showed that auditory stimulation of 1-8 msec duration may be particularly effective for Aβ clearance. However, quantitative evaluation of Aβ has not yet been conducted. Therefore, in this study, we quantitatively evaluated the effect of auditory stimulation on Aβ clearance by analyzing the amount of Aβ. As a result, auditory stimulation using a sound with a period of 40 Hz, a pitch of 10 kHz, and a duration of 3 msec reduced the magnitude of Aβ.
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