Abstract
Cerebral amyloid angiopathy (CAA) is a common disease in the older age group with high clinical and neurovisual heterogeneity. A literature review and two clinical cases reflecting different phenotypes of CAA are presented — amyloid angiitis (CAA-related inflammation) and “hemorrhagic phenotype” (CAA associated with intracerebral hemorrhage and progressive cortical superficial siderosis). In each case, in relation to the clinical and neuroimaging picture, the directions of the disputed vectors of secondary prevention and therapy of CAA are considered: antithrombotic, antihypertensive and lipid-lowering therapy. The issues of epidemiology, pathogenesis, diagnosis and treatment of CAA are discussed.
Highlights
AMYLOID ANGIITIS AND PROGRESSIVE CORTICAL SUPERFICIAL SIDEROSIS AS AGGRESSIVE PHENOTYPES OF CEREBRAL AMYLOID ANGIOPATHY: PRINCIPLES OF RATIONAL MANAGEMENT Kulesh A.A.1,2, Gorst N.Kh.1, Kuzina E.V.3, Drobakha V.E.1,2, Shestakov V.V.1, Karakulova Yu.V.1 1E.A
A literature review and two clinical cases reflecting different phenotypes of Cerebral amyloid angiopathy (CAA) are presented — amyloid angiitis (CAA- related inflammation) and “hemorrhagic phenotype” (CAA associated with intracerebral hemorrhage and progressive cortical superficial siderosis)
В клинической картине преобладают когнитивных нарушений (КН) (у 48% пациентов), судорожные приступы (32%), головная боль (32%), спутанность и другие нарушения сознания (27%); реже встречаются парезы (16%), афазия (14%) и нарушение зрения (13%)
Summary
AMYLOID ANGIITIS AND PROGRESSIVE CORTICAL SUPERFICIAL SIDEROSIS AS AGGRESSIVE PHENOTYPES OF CEREBRAL AMYLOID ANGIOPATHY: PRINCIPLES OF RATIONAL MANAGEMENT Kulesh A.A.1,2, Gorst N.Kh.1, Kuzina E.V.3, Drobakha V.E.1,2, Shestakov V.V.1, Karakulova Yu.V.1 1E.A. [13], а именно возраста, наличия головной боли и судорожных припадков (не связанных с ВМК), мультифокального, асимметричного, корково-подкоркового поражения белого вещества головного мозга по данным МРТ, признаков ЦМК и КПС, а также отсутствия опухолевой, инфекционной или другой причины заболевания, установлена ЦАА-В.
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