Abstract
Amylin aggregation is associated with type 2 diabetes. The interaction of intermediate small oligomers with the membrane is a crucial step in their toxicity and is dependent on the membrane order. But the exact role of membrane phases in amylin toxicity is not known. Therefore, understanding the interaction of the toxic small oligomers of amylin with the coexisting membrane phases and elucidating the role of phase boundaries are important. Here, we have used biphasic supported lipid bilayers and studied membrane phase-dependent interactions of amylin oligomers using a home-built combined atomic force (AFM)-fluorescence confocal -fluorescence lifetime imaging set-up.
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