Abstract
AbstractThe sections in this article are:Protein Chemistry of AmylinIsolation, Structure, Nomenclature, and Evolutionary RelationshipsChemical SynthesisMolecular Structure of Soluble AmylinAmylin as the Monomer of Islet AmyloidMolecular BiologyPreproamylinStructure and Chromosomal Location of the Human Amylin GeneA Disease‐Associated Mutation in Human AmylinBiosynthesis and Secretion of AmylinMeasurement of Amylin ConcentrationsTissue Localization and ContentRegulation of BiosynthesisAmylin in Extra‐Islet TissuesCirculating Concentrations and Pancreatic SecretionEffects of Secretion ModulatorsAmylin Secretion in HumansThe Amylin Family: Role in the Regulation of Fuel MetabolismInsulin Resistance In VivoActions in Skeletal MuscleRole of Calcitonin Gene‐Related Peptide in Skeletal Muscle MetabolismActions in the LiverAdipose TissueRegulation of Pancreatic FunctionEndocrine PancreasExocrine PancreasRegulation of The Gastrointestinal TractEffects on Gastric FunctionIntestinal FunctionActions in The Central Nervous System: Modulation of AppetiteActions in The Cardiovascular SystemCalcitonin Gene‐Related PeptideAdrenomedullinBiological Actions of Adrenomedullin in the Cardiovascular SystemVascular Actions of AmylinRenal FunctionRole of Amylin in the Regulation of Renal FunctionAdrenomedullin: Roles in Renal Function and Sodium HomeostasisEffects on Calcium Metabolism and BoneActions of AmylinOther Biological ActionsRespiratory SystemEffects in Endocrine Tissues Other than PancreasEffects in the Immune SystemReceptors for Amylin and Related ProteinsReceptor NomenclaturePharmacological and Biochemical StudiesCalcitonin ReceptorsSpecific Calcitonin Gene‐Related Peptide Binding Sites that Can Interact with AmylinAmylin Binding to Skeletal Muscle and LiverBiochemical Characterization of Putative Amylin and Calcitonin Gene‐Related Peptide ReceptorsDisease AssociationsInsulin‐Dependent Diabetes MellitusAnimal Models of Insulin Resistance, Obesity, and DiabetesObesity and Non‐Insulin‐Dependent Diabetes Mellitus in HumansOther Diabetic SyndromesAmylin in Endocrine NeoplasmsRelationship to AgingOther DiseasesConclusion and Future Prospects
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