Abstract
The present study was undertaken to evaluate in-vitro antioxidant and anthelmintic activity of ethanolic and aqueous extract from whole plant Sida cordifolia Linn (Malvaceae). The antioxidant activities are evaluated by various antioxidant assays like α, α-Diphenyl-β-picrylhydrazyl (DPPH) free radical scavenging, total reducing power, nitric oxide scavenging and hydrogen peroxide scavenging. The various antioxidant activities were compared to standard antioxidants such as ascorbic acid. The antioxidant activity of ethanolic extract is almost quantitatively equivalent to that of the standards used, ascorbic acid. The further anthelmintic activity of whole plant is investigated through using Indian earthworm (Pheretima posthuma) showed that it is one of the most important local medicinal plants both for ritual and ethnomedical practices. Various concentrations of ethanol and aqueous extract (10, 20, 30, 40 mg/ml) of whole plant of Sida cordifolia Linn were tested in the bioassay, which involve determination of time of paralysis of the worms. Albendazole was included as reference standard. The most activity was observed with aqueous extract as compared to standard drug. The results from the above studies indicate that plant Sida cordifolia Linn. possesses potent antioxidant and anthelmintic activity.
Highlights
IntroductionRoots of the plant which constitute a drug are 5 - 15 cm long with few lateral roots of smaller size
Ethanol and aqueous extract of plant Sida cordifolia were dissolved in minimum amount of Dimethyl formamide (DMF) and the volume was adjusted to 10 ml with saline water
The results showed that aqueous extract of Sida cordifolia plant took least time to cause paralysis and death of the earthworms (Table 2)
Summary
Roots of the plant which constitute a drug are 5 - 15 cm long with few lateral roots of smaller size. It is almost odorless with slightly bitter taste [2]. Franco et al tested that rather than being a stimulant, Sida cordifolia acts as a depressant and decreases CNS activity [5]. It acts as a weight loss product is through its hypoglycemic (blood sugar lowering) activity [6]. The drug has demonstrated antibacterial, antiplaque and antifungal activities. The present study was undertaken to validate its anthelmintic and antioxidant activity
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