Abstract
Antibacterial activity of iron oxide nanoparticles, an employing B. aegyptiaca oil (L.) Del., was used as natural stabilizer by modifying a co-precipitation method. In this work, we chose B. aegyptiaca oil as the new surfactant coating agent, and synthesized B. aegyptiaca oil coating with iron oxide nanoparticles which were characterized with a variety of methods, including Gas Chromatography (GC) to determine the fatty acids composition of the seeds oil, Fourier Transform-Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM) equipped with Energy Dispersive Spectroscopy (EDS), X-ray Powder Diffractometer (XRD) and Vibrating Sample Magnetometer (VSM). In antibacterial studies, disk diffusion susceptibility test was used to measure efficacy of iron oxide nanoparticles against Gram-positive bacteria Staphylococcus aureus (S. aureus), Bacillus subtilis (B. subtilis) and Gram-negative bacteria Escherichia coli (E. coli) in terms of zone inhibition. The B. aegyptiaca coated on the surface of iron oxide nanoparticles; its particle size was found to be nanoscale below 50 nm, and the magnetization (δs) was 16.975 emu g-1. Antibacterial activity was measured. Efficacy of iron oxide nanoparticles against bacterial strains was found in Escherichia coli (E. coli). All these findings suggest that the nanoparticles synthesized from B. aegyptiaca oil may be a promising reagent for a wide variety of applications in biological fields as well as in nanomedicine.
Highlights
Nanotechnology had an enormous impact on medical technology, significantly improving the activity, specificity, bioavailability and therapeutic index of various natural products [1]
Plant oil extracts are being used as a process for the synthesis of iron oxide nanoparticles that may find very important place in antibacterial activity
This study aims to explore the efficacy of magnetic iron oxide nanoparticles (Fe3O4) synthesized with B. aegyptiaca oil (L.) Del., as novel reagent to detect the bacteria strains
Summary
Nanotechnology had an enormous impact on medical technology, significantly improving the activity, specificity, bioavailability and therapeutic index of various natural products [1]. By using nanoscale carriers, the therapeutic value of natural products can be drastically improved [2]. In the past two decades, some studies have shown that antimicrobial formulations in the form of nanoparticles could be used as effective bactericidal materials because of their high surface-to-volume ratio and novel physical and chemical properties on the nanoscale level [3]. Iron oxide nanoparticles have been extensively studied in biomedical applications because of their unique properties, such as easy handling, low cytotoxicity, good biocompatibility, relatively low cost and eco-friendly performance [4]
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