Amplitude of Low-Frequency Oscillations in Major Depressive Disorder With Childhood Trauma.

Jianfei He,Zhiyao Wu,Zhuoying Wu,Yuling Yang,Yingjun Zheng,Rongjun Yu,Yi Ding,Qianyi Luo,Hongjun Peng,Huawang Wu

doi:10.3389/fpsyt.2020.596337

Jianfei He, Zhiyao Wu + Show 8 more

Open Access

https://doi.org/10.3389/fpsyt.2020.596337

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Abstract

Major Depressive Disorder (MDD) with childhood trauma is one of the functional subtypes of depression. Frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) have been reported in MDD patients. However, there are few studies on ALFF about MDD with childhood trauma. Resting-state functional magnetic resonance imaging was used to measure the ALFF in 69 MDD patients with childhood trauma (28.7 ± 9.6 years) and 30 healthy subjects (28.12 ± 4.41 years). Two frequency bands (slow-5: 0.010–0.027 Hz; slow-4: 0.027–0.073 Hz) were analyzed. Compared with controls, the MDD with childhood trauma had decreased ALFF in left S1 (Primary somatosensory cortex), and increased ALFF in left insula. More importantly, significant group × frequency interactions were found in right dorsal anterior cingulate cortex (dACC). Our finding may provide insights into the pathophysiology of MDD with childhood trauma.

Highlights

Major depressive disorder (MDD) is described as long sadness and interest loss in generally pleasant activities, following with inability to perform daily activities, over a period of at least 2 weeks [1]
There is no significant difference in gender, education state, age between two groups
Our study found that the frequency-dependent changes in the amplitude of low-frequency fluctuations (ALFF) occur in MDD patients with childhood trauma

Summary

Introduction

Major depressive disorder (MDD) is described as long sadness and interest loss in generally pleasant activities, following with inability to perform daily activities, over a period of at least 2 weeks [1]. At present, depending on its characteristics, MDD can be divided into different subtypes [2]. Some scholars believe that MDD with childhood trauma may be one of the functional subtypes of depression [5]. Previous studies have found that nearly half of depression patients have experienced childhood trauma [7, 8], and their clinical characteristics are different from those of ordinary depression patients [9]. There are some specific changes in brain imaging of depression patients with childhood trauma. Brain network studies reported that there are constant disruptions of resting-state networks (RSNs) in patients with MDD, including increased connection between the DMN and FPN, hyperconnectivity in the default mode network (DMN), and hyporconnectivity in the frontoparietal network (FPN) [11]. Saleh et al reported that in depressive subjects, greater early life stress exposure was linked to slower processing speeds and smaller orbitofrontal cortex volumes; in non-depressive subjects, it was associated

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