Abstract
BackgroundCognitive impairments are prominent in schizophrenia (SZ). Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. This study was conducted to explore the relationship between cognitive functional impairment and the amplitude of low-frequency fluctuation (ALFF) in SZ patients.MethodA total of 104 participants (44 SZ patients and 60 age- and gender-matched healthy controls (HC)) were recruited for this study. The MCCB was used to assess cognitive function of the participants, while brain activity was assessed using the ALFF. The relationship between the MCCB and the ALFF was investigated by using a correlation analysis.ResultsThere were significant differences between SZ patients and HC in MCCB total and domain scores as well as in ALFF results. The reduction of ALFF in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MCCB sub-test of symbol coding.ConclusionThese findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients.
Highlights
Cognitive impairments are prominent in schizophrenia (SZ)
The reduction of amplitude of low-frequency fluctuation (ALFF) in the bilateral postcentral gyri and paracentral lobule in SZ patients has a negative correlation with the MATRICS Consensus Cognitive Battery (MCCB) sub-test of symbol coding
These findings suggest that the reduction of ALFF in bilateral postcentral gyri and paracentral lobule may be related to cognitive impairment in SZ patients
Summary
Imaging studies have demonstrated that functional changes of several areas of the brain exist in SZ patients. The relationships between these two indexes are largely unexplored in SZ. The MATRICS Consensus Cognitive Battery (MCCB) was used to measure cognitive impairment in multi-dimensional cognitive fields of SZ patients. Several studies have reported multiple cognitive impairments in SZ patients, The US National Institute of Mental Health (NIMH) developed the Measurement and Treatment Research to Improve Cognition in Schizophrenia (MATRICS) initiative to stimulate the development of new drugs that address the cognitive deficits associated with schizophrenia. The measurement of the cognitive impairment of SZ patients is estimated based on test–retest reliability, high utility as a repeated measure, relationship to functional outcome, potential changes in response to pharmacological agents, tolerability, and practicality [9, 12]. After the MCCB was translated into Chinese, the clinical reliability and validity of MCCB were established between SZ patients and HC [16] to allow for its widespread use in cognitive research in SZ patients in China [17,18,19]
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