Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity

Keiko Kumagai,Eri Fukushi,Masashi Tsuda,Akira Tominaga,Mai Akakabe,Jun Kawabata,Yuko Konishi,Masayuki Tsuda

doi:10.1016/j.tetlet.2014.04.086

Amphirionin-5, a novel linear polyketide from a cultured marine dinoflagellate Amphidinium species with a potent cell proliferation-promoting activity

Keiko Kumagai, Eri Fukushi + Show 6 more

https://doi.org/10.1016/j.tetlet.2014.04.086

Copy DOI

Journal: Tetrahedron Letters	Publication Date: May 2, 2014
Citations: 24

Affiliation: Kōchi University, Hokkaido University

#Linear Polyketide #Dinoflagellate Amphidinium + Show 8 more

Abstract
Full-Text PDF
Similar Papers

Abstract

A novel linear polyketide, amphirionin-5 (1), has been isolated from the cultivated algal cells of the benthic dinoflagellate Amphidinium sp. (strain KCA09053), and the structure was elucidated on the basis of detailed analyses of 1D and 2D NMR data. Amphirionin-5 (1) resulted in a 282% increase in the proliferation of murine bone-marrow derived stromal ST-2 cells and 320% increase in the proliferation of murine osteoblastic MC3T3-E1 cells.

Full Text