Amphiphilic Polymer-Modified Uniform CuFeSe2 Nanoparticles for CT/MR Dual-Modal Imaging.

Min Wu,Jian Shu,Shaozhi Fu,Kequan Yu,Changning Wang

doi:10.1155/2020/4891325

Abstract

Recently, magnetic photothermal nanomaterials have attracted much attention in the diagnosis and treatment of cancer. In this study, we developed the ultrasmall magnetic CuFeSe2 nanoparticles for CT/MR dual-modal imaging. By controlling the reaction time and condition, CuFeSe2 nanoparticles were synthesized by a simple directly aqueous method. After modification with copolymer methoxy polyethylene glycol-polycaprolactone (MPEG-PCL), the obtained MPEG-PCL@CuFeSe2 nanoparticles showed excellent water solubility, colloidal stability, and biocompatibility. In addition, they also exhibited superparamagnetism and X-ray's characteristics. For these properties, they will become ideal nanomaterials for CT/MR dual-modal imaging.

Highlights

In recent years, nanotechnology has been widely used in the field of biomedicine, such as the development of tumor therapeutic drugs and molecular imaging probes [1, 2]
The CuFeSe2 nanostructures can be prepared by the solvothermal reaction [19] and the high-temperature solid phase reaction [16]. e products which are often synthesized tend to have a nonuniform size and are prone to agglomeration. erefore, in an effort to overcome their disadvantages of CuFeSe2 nanostructures, we attempted to prepare with biodegradable copolymer loaded CuFeSe2 nanocrystals to increase the solubility in aqueous media
In Vivo Toxicity Study. e major organs/tissues were taken from mice after intravenous injection of MPEG-PCL@ CuFeSe2 at 1 day, 3 days, 7 days, and 15 days postinjection, while other mice without injection were used as the control group. en, the obtained major organs/tissues were fixed in 4% formalin, paraffin-embedded, sectioned, and stained with hematoxylin & eosin (H&E) and imaged by using a digital microscope to evaluate the histological changes

Summary

Introduction

Nanotechnology has been widely used in the field of biomedicine, such as the development of tumor therapeutic drugs and molecular imaging probes [1, 2]. Erefore, we will try to explore the potential value of its application in the field of imaging diagnosis. Erefore, it can be used to load CuFeSe2 nanoparticles for molecular imaging in vivo. Multimodal imaging can improve the accuracy of cancer diagnosis by combining two or more imaging modalities into one system [25, 26]. It overcomes the intrinsic limitations of single modality. The X-ray attenuation property and T2MR relaxometry of MPEG-PCL@CuFeSe2 NPs in vitro/in vivo were measured to explore the potential application of these NPs as dual-modal CT/MR imaging contrast agents

Experimental Section

Results and Discussion

Conclusions