Abstract
New nanoscaled polymeric carriers have been prepared onthe basis of different amphiphilic water-soluble derivatives ofpoly-N-vinylpyrrolidone (PVP). The polymer self-assembly and interaction with model proteins(Bowman–Birk soybean proteinase inhibitor (BBI) and its hydrophobized derivatives) werestudied in aqueous media. The possibility of inclusion of both BBI and hydrophobized oleicacid derivatives of BBI in amphiphilic PVP aggregates was investigated. It was ascertainedthat polymeric particles of size 50–80 nm were formed in certain concentrations ofamphiphilic PVP and poorly soluble dioleic acid derivatives of BBI. Such polymericaggregates are capable of solubilization of dioleoyl BBI with a concomitant prevention of itsinactivation at low pH values.
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