Abstract
Poly (3-hydroxy alkanoate)s, PHAs, have been very attractive as biomaterials due to their biodegradability and biocompatibility. These hydrophobic natural polyesters, PHAs, need to have hydrophilic character particularly for drug delivery systems. In this manner, poly (ethylene glycol) (PEG) and hydrophilic functional groups such as amine, hydroxyl, carboxyl and sulfonic acid have been introduced into the PHAs in order to obtain amphiphilic polymers. This review involves in the synthesis and characterization of the amphiphilic PHAs.
Highlights
IntroductionBiomaterials have been widely used in medical applications, such as drug delivery, tissue engineering, devicebased therapies and medical imaging [1,2]
Poly (PEG) and hydrophilic functional groups such as amine, hydroxyl, carboxyl and sulfonic acid have been introduced into the PHAs in order to obtain amphiphilic polymers
This review involves in the synthesis and characterization of the amphiphilic PHAs
Summary
Biomaterials have been widely used in medical applications, such as drug delivery, tissue engineering, devicebased therapies and medical imaging [1,2]. PHAs are accumulated as intracellular granules as a result of a metabolic stress upon imbalanced growth due to a limited supply of an essential nutrient and the presence of an excess of a carbon source These novel biopolymers have material properties ranging from rigid and highly crystalline to flexible, rather amorphous and elastomeric. Pseudomonas oleovorans is a very versatile for PHA production because it can produce medium chain length polyesters (mclPHA) and long chain length polyesters (lclPHA) from a wide variety of carbon substrates.
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