Abstract
This work presents the utilization of amphiphilic poly(oligo(ethylene glycol) methyl methacrylate)-co-poly(2-(diisopropylamino)ethyl methacrylate), P(OEGMA-co-DIPAEMA), hyperbranched (HB) copolymers, forming polymeric aggregates in aqueous media, as building nanocomponents and nanocarriers for the entrapment of magnetic cobalt ferrite nanoparticles (CoFe2O4, MNPs), and the hydrophobic drug curcumin (CUR) in their hydrophobic domains. Dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM) techniques were used to evaluate the multifunctional hybrid nanostructures formed in aqueous media by co-assembly of the components and their solution properties. Magnetic nanoparticles (MNPs) or MNPs/CUR were co-assembled effectively with pre-existing polymer aggregates, leading to well-defined hybrid nanostructures. Magnetophoresis experiments revealed that the hybrid nanostructures retain the magnetic properties of MNPs after their co-assembly with the hyperbranched copolymers. The hybrid nanostructures demonstrate a significant colloidal stability under physiological conditions. Furthermore, MNPs/CUR-loaded aggregates displayed considerable fluorescence as demonstrated by fluorescence spectroscopy. These hybrid nanostructures could be promising candidates for drug delivery and bio-imaging applications.
Highlights
IntroductionMagnetic nanoparticles (MNPs)/CUR-loaded aggregates displayed considerable fluorescence as demonstrated by fluorescence spectroscopy
Magnetic nanoparticles (MNPs)-stabilized with oleic acid which were interacting with the hydrophobic domains of the aggregates
Multifunctional hybrid nanostructures formed by P(OEGMA-co-DIPAEMA) amphiphilic hyperbranched copolymers in aqueous media, were studied in detail
Summary
MNPs/CUR-loaded aggregates displayed considerable fluorescence as demonstrated by fluorescence spectroscopy These hybrid nanostructures could be promising candidates for drug delivery and bio-imaging applications. Introduction with regard to jurisdictional claims in Polymeric materials that act as a drug used for imaging and therapeutic agents simultaneously have gained the interest of the scientific community in recent years They are being extensively developed and constructed due to their multi-functionality for the cure of various life-threatening diseases. Hyperbranched polymers have many advantages in being used as nanocomponents for a wide range of biomedical applications, such as drug delivery and bio-imaging, due to their unique properties. More importantly they exhibit small sizes at the nanoscale, similar to dendrimers.
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