Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers.

Jessica Wagner,Volker Mailänder,Johanna Simon,Marcel Dillenburger,Katharina Landfester,David Y W Ng,Jennifer Oberländer,Tanja Weil,Klaus Müllen

doi:10.1039/d0cc02486d

Abstract

Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied. The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches.

Highlights

Jessica Wagner,‡ab Marcel Dillenburger,‡a Johanna Simon,ac Jennifer Oberlander,ac Katharina Landfester, a Volker Mailander, ac David Y
Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied
The PPD corona reduced binding of specific opsonins and increased the adsorption of proteins controlling cellular uptake based on their surface patches

Summary

Introduction

Jessica Wagner,‡ab Marcel Dillenburger,‡a Johanna Simon,ac Jennifer Oberlander,ac Katharina Landfester, a Volker Mailander, ac David Y. Amphiphilic dendrimers control protein binding and corona formation on liposome nanocarriers† Amphiphilic polyphenylene dendrimers (PPDs) with distinct lipophilic and positively or negatively charged surface groups were adsorbed onto liposomes and their impact on protein adsorption in blood plasma was studied.

Results

Conclusion