Abstract
This work presents the first example of utilization of amphiphilic block copolymer PCL-PEG-PCL as a stationary phase for capillary gas chromatographic (GC) separations. The PCL-PEG-PCL capillary column fabricated by static coating provides a high column efficiency of 3951 plates/m for n-dodecane at 120 °C. McReynolds constants and Abraham system constants were also determined in order to evaluate the polarity and possible molecular interactions of the PCL-PEG-PCL stationary phase. Its selectivity and resolving capability were investigated by using a complex mixture covering analytes of diverse types and positional, structural, and cis-/trans-isomers. Impressively, it exhibits high resolution performance for aliphatic and aromatic isomers with diverse polarity, including those critical isomers such as butanol, dichlorobenzene, dimethylnaphthalene, xylenol, dichlorobenzaldehyde, and toluidine. Moreover, it was applied for the determination of isomer impurities in real samples, suggesting its potential for practical use. The superior separation performance demonstrates the potential of PCL-PEG-PCL and related block copolymers as stationary phases in GC and other separation technologies.
Highlights
Capillary gas chromatography (GC) is one of efficient separation techniques in petrochemical engineering, environmental protection, food analysis, and biological medicine because of its inherent advantages of high resolving capability and selectivity, fast analysis speed, as well as low cost [1,2,3,4].As the core component in GC system, a stationary phase with high selectivity enables effective separation of analytes with close nature
Polymeric materials with good solubility and film-forming ability, wide operational temperature range, and high chemical/thermal stability are advantageous as stationary phase in GC separations
We present a new strategy for the preparation and application of amphiphilic block copolymer as highly selective GC stationary phase
Summary
Capillary gas chromatography (GC) is one of efficient separation techniques in petrochemical engineering, environmental protection, food analysis, and biological medicine because of its inherent advantages of high resolving capability and selectivity, fast analysis speed, as well as low cost [1,2,3,4]. Modifying the side chains of polymer by different organic molecules is a common strategy to fine tune the polarity and selectivity of stationary phases [16,17,18]. We present a new strategy for the preparation and application of amphiphilic block copolymer as highly selective GC stationary phase. We present a new strategy for the preparation and application of amphiphilic block Molecules 2019, 24, 3158 copolymer as highly selective GC stationary phase. The amphiphilic triblock copolymer of PCL-PEG-PCL can be synthesized via the ring-opening. We present the report of using PCL-PEG-PCL as a stationary phase for GC separations was statically coated onto fused-silica capillarycapillary column. TheMoreover, prepared PCL-PEG-PCL column was applied forwas the mixtures of diverse isomers. The prepared PCL-PEG-PCL column detectionfor of impurity isomers in real samples.
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