Abstract
Summary Cells with the light microscopic and ultrastructural features of mamalian plasma cells were observed in lympoid tissues of long-term stimulated Bufo marinus, the marine toad. Cells with this morphology were the only cells which could be stained by the fluorescent antibody method. The cellular basis of immunoglobulin formation in cold-blooded vertebrates thus appears to be the same as that in mammals. Bufo marinus plasma cells were most abundant in the kidney lymphoid tissue, and in the margins of granulomas formed at the sites of injection of antigen in complete adjuvant.
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