Abstract

1. 1. Acid phosphatase activity is influenced by parathyroid hormone in amphibian skeletal tissues and plasma. 2. 2. The enzymatic response to parathormone is tissue-specific, varying in time, magnitude and direction of change. 3. 3. The diaphysis and epiphysis of the femur respond slowly to parathyroid extract treatment; at 1 hr after injection, acid phosphatase activities were little changed from control levels, but subsequently, a progressive increase was observed. Plasma enzyme activity rises through 4 hr. 4. 4. The metaphyseal plate of the femur and the spongy coracoid bone of the pectoral girdle respond rapidly and strongly to hormone treatment; from 1–4 hr after injection, their acid phosphatase activities are significantly elevated. 5. 5. Daily hormone treatment for 1 week elevates acid phosphatase activity in plasma and all skeletal tissues studied except femoral epiphysis. On day 8, enzyme activity of the latter had sharply declined. 6. 6. A significant hypercalcemia accompanies the enzymatic changes in skeletal tissues and plasma.

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