Abstract
Catecholamine release and reuptake are considerably more stereoselective at norepinephrine than at dopamine nerve terminals, suggesting that pronounced differences in the influence of amphetamine isomers on particular behaviors favors norepinephrine mediation while similar actions of these isomers indicates a predominant role for dopamine. (+)-Amphetamine is markedly more potent than its (−)-isomer in stimulating locomotor activity of the cat while the two isomers differ less in provoking stereotyped behavior. These findings support a major role for brain norepinephrine in mediating amphetamine-induced locomotor enhancement, while dopamine may be more important in facilitating stereotyped behavior. Besides inducing stereotyped behavior, L-Dopa greatly enhances locomotor activity, which suggests an important role for dopamine in mediating locomotor activation.
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