Abstract
Amphetamine, 0.5 mg/kg administered on five successive trials, significantly depressed the operant performance of both male and female rats maintained on a multiple CRF-EXT schedule. That the depression of behavior was due to the drug was indicated by the recovery of performance in both sexes on two subsequent distilled water injection trials. Some basic sex differences in reaction to the reinforcement schedule also were observed on all trials of the study.
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