Abstract
Background: The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (AMPD1) is associated with muscular energy metabolism in exercise. However, the role of its potential modifying impact on exercise-induced changes in obesity related parameters is unknown. The aim of the study was to determine if the C34T polymorphism influences the effects of an exercise training. Methods: This study examines a group of one hundred and sixty-eight, young, non-obese Caucasian women in Poland who took part in a 12-week aerobic training program to determine the impact of allele and genotype distribution on training outcomes. Results: A two-way analysis of variance ANOVA was conducted assuming a dominant model by pooling rare homozygotes and heterozygotes (TT + CT, n = 79) and comparing against common homozygotes (CC, n = 89). Our results showed that the AMPD1 C34T polymorphism was not related with selected parameters in study group. After completing the 12-week training program, a wide array of parameters (body mass, body mass index, fat mass, free fat mass, total body water) were significantly changed in the study participants with the exception of AMPD1 genotypes, among whom no significant changes were observed. Conclusions: The results did not confirm that harboring the rs 17602729 T allele influences the effects of the training program.
Highlights
It is well known that the acute responses [1,2] as well adaptive changes in the human body following physical exercise show wide individual variance [3]
Our main findings are that the common C34T polymorphism in adenosine monophosphate deaminase 1 gene (AMPD1) gene was not associated with selected body mass, body composition, and biochemical parameters in young, nonobese Caucasian women
Body mass, Body mass index (BMI), %Fat mass (FM), FM, Free fat mass (FFM), Total body water (TBW), HDL, and glucose changed significantly in the course of the 12-week aerobic training program, these parameters did not change across the AMPD1 genotypes
Summary
It is well known that the acute responses [1,2] as well adaptive changes in the human body following physical exercise show wide individual variance [3]. Changes in weight, body composition, and biochemical parameters in response to training programs may be more effective for some genotypes than others. The C34T polymorphism (rs 17602729) in adenosine monophosphate deaminase 1 gene (AMPD1) is associated with muscular energy metabolism in exercise. The aim of the study was to determine if the C34T polymorphism influences the effects of an exercise training. Our results showed that the AMPD1 C34T polymorphism was not related with selected parameters in study group. After completing the 12-week training program, a wide array of parameters (body mass, body mass index, fat mass, free fat mass, total body water) were significantly changed in the study participants with the exception of AMPD1 genotypes, among whom no significant changes were observed. Conclusions: The results did not confirm that harboring the rs 17602729 T allele influences the effects of the training program
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