Abstract
Abstract. SIRT1 is the gene that codes for Sirtuin 1, an NAD (nicotinamide adenine dinucleotide)-dependent class III histone deacetylase. This gene plays a key role in adipose tissue and muscle development in animals. Chinese Luxi cattle (n = 169) were selected to identify SIRT1 SNPs (single nucleotide polymorphisms) and investigate the relationship of these SNPs with carcass traits. Five SNPs (g.-382G > A, g.-274C > G, g.17324T > C, g.17379A > G, and g.17491G > A) were identified by direct sequencing. SNPs g.-382G > A and g.-274C > G were located within the promoter region of this gene. SNP g.-382G > A was significantly associated with dressing percentage, meat percentage, and striploin and ribeye weights, and the g.-274C > G polymorphism had a strong effect on carcass, tenderloin, and high rib weights in Luxi cattle. These findings will provide possible clues for the biological roles of SIRT1 underlying beef cattle carcass traits.
Highlights
Sirtuin 1, known as NAD-dependent deacetylase Sirtuin 1, is an NAD+dependent protein deacetylase; it has many established protein substrates and is thought to regulate an impressive list of biological functions (McBurney et al, 2013)
There are several variants associated with body mass index and risk of obesity in human SIRT1 gene (Zillikens et al, 2009)
We identified five SNPs in bovine SIRT1 and estimated the extent of associations between these SNPs and carcass traits in Chinese Luxi cattle
Summary
Sirtuin 1, known as NAD (nicotinamide adenine dinucleotide)-dependent deacetylase Sirtuin 1, is an NAD+dependent protein deacetylase; it has many established protein substrates and is thought to regulate an impressive list of biological functions (McBurney et al, 2013). In the pancreatic β cells, SIRT1 positively regulates insulin secretion in response to glucose (Bordone et al, 2006) It is involved in cellular differentiation, apoptosis, metabolism, and aging (Shakibaei et al, 2012; Sasaki et al, 2014; Luna et al, 2013; Gueguen et al, 2014). PPAR-γ is a key regulator in adipogenesis and fat storage, controlling the expression of many adipocyte-specific genes (Picard et al, 2004). These studies suggested that Sirtuin 1 is a key regulator of whole-body energy balance and plays a role in human health (Sasaki et al, 2014). Liu et al.: SIRT1 gene polymorphisms associated with carcass traits in Luxi cattle
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