Abstract
The use of plants to improve dental health and to promote oral hygiene has been practiced for centuries and persists in several communities throughout the world. Salvadora persica (Miswak) has a wide geographic distribution. The ancient Arabs had the habit of using it to whiten and polish the teeth. Here, we determined in vitro antioxidant activity, total phenols and flavonoids and evaluated antiproliferative activity of the extract of S. persica (Miswak). The MTT assay was used to estimate the antiproliferative activities of the extract against human hepatoma (HepG2) cancer cell line. Inhibition percentage of DPPH scavenging activity was dose-dependent and ranged from (30.7% ± 0.62) to (5.89% ± 0.98). The phenolic content was (2.7 ± 0.11) mg GAE/g while the flavonoid content was (2.70 ± 0.45) mg QE/g. Antiproliferative results of the extracts were found to be consistent with their antioxidant activity. Our extract also exhibited clear antiangiogenic activity. These findings introduce S. persica as the useful and novel potential anti-tumor agent for hepatocellular carcinoma (HCC) treatment.
Highlights
Free radicals have been found to play an important role in food rancidity, chemical materials degradation and damage of macromolecules such as lipids, nucleic acids, proteins and carbohydrates [1]
The current study investigates the total phenolic and flavonoid contents in the hydroalcoholic extract of S. persica roots which is one of the most traditionally plant used in the United Arab Emirates (UAE)
The plant kingdom is a good source of natural antioxidants used for health promotion
Summary
Free radicals have been found to play an important role in food rancidity, chemical materials degradation and damage of macromolecules such as lipids, nucleic acids, proteins and carbohydrates [1]. Free radicals contribute to certain human disorders such as cardiovascular diseases, diabetes, cancer and in-. Free radicals and other reactive oxygen species (ROS) derived from normal essential metabolic processes are major contributors of oxidative damage in the human body. Human body is significantly exposed to external sources of free radicals such as X-rays, ozone, cigarette smoking, air pollutants, and industrial chemicals [5]. ROS represents the major type of free radicals in the biological systems. They are produced through the mitochondrial electrons transport chain [3] [6]. Antioxidant complements are important to boost the body’s own capacity to reduce or neutralize the oxidative damages [7]
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