Abstract
<i>Momordica charantia</i> Ameliorates Atopic Dermatitis by Inhibiting the Expression of Inducible Nitric Oxidase Synthase in NC/Nga Mice
Highlights
Momordica charantia (MC) has been reported to possess various beneficial effects
These ADlike symptoms were improved in conventional NC/Nga mice treated with MC (Figure 1(A) and Figure 1(B))
The present study indicates that MC administration may suppress filaggrin degradation by suppressing the expression of LPS, inducible nitric oxidase synthase (iNOS), and COX2/prostaglandin E2 (PGE2)
Summary
Momordica charantia (MC) has been reported to possess various beneficial effects. Improvement in natural aging of the skin has been observed with the use of MC. Results: The expression levels of lipopolysaccharide (LPS), inducible nitric oxidase synthase (iNOS), and prostaglandin E2 (PGE2) remarkably increased in AD, but were suppressed by MC administration. Due to suppression of iNOS with MC administration, macrophages shifted to type 2 and an increase in L-ornithine was observed, which subsequently promoted filaggrin synthesis. Both forms involve thickened skin with an acidic pH, reduced stratum corneum hydration, and elevated transepidermal water loss and erythema index due to changes at the tissue and cellular levels [1]. Filaggrin is a protein of the horny layer that plays an important role in the skin barrier function. In an AD mouse model, inhibition of filaggrin gene expression was observed, which led to a decrease in skin barrier function. Skin barrier function can be improved by accelerating the expression of filaggrin [6]
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