Abstract
Dietary intake of 0.1% fucoxanthin significantly reduced lipid hydroperoxide levels of liver and abdominal white adipose tissue (WAT) of obese/diabetes KK-Ay mice. The fucoxanthin supplementation also significantly reduced blood glucose level and hepatic lipid contents of the mice. Oxidative stress is known to be induced in hyperglycemia and high fat conditions. Therefore, in vivo antioxidant activity of fucoxanthin found in the present study could be attributed to its anti-diabetic effect and its decreasing effect on hepatic lipids. On the other hand, little effect of fucoxanthin on lipid hydroperoxide levels was found in normal ICR mice. Although the content of fucoxanthin metabolites in the abdominal WAT of KK-Ay mice was about 50 times higher that in the liver, there was little difference in its In Vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its In Vivo antioxidant activity.
Highlights
Polyphenols and carotenoids have been implicated as important dietary nutrients having antioxidant potential
The content of fucoxanthin metabolites in the abdominal white adipose tissue (WAT) of KK-Ay mice was about 50 times higher that in the liver, there was little difference in its in vivo antioxidant activity between in the liver and in the abdominal WAT. These results suggest that well-known ability of fucoxanthin to scavenge active oxygen species and/or free radicals would not be a main reason to explain its in vivo antioxidant activity
We have found that hepatic lipid hydroperoxide levels of mice fed brown seaweed lipids containing fucoxanthin, a characteristic carotenoid found in brown seaweeds, were significantly lower than that of control mice, even though total polyunsaturated fatty acids (PUFAs) content in the liver of mouse fed the brown seaweed lipids was higher than that of mouse fed control diet [2]
Summary
Polyphenols and carotenoids have been implicated as important dietary nutrients having antioxidant potential. We have found that hepatic lipid hydroperoxide levels of mice fed brown seaweed lipids containing fucoxanthin, a characteristic carotenoid found in brown seaweeds, were significantly lower than that of control mice, even though total polyunsaturated fatty acids (PUFAs) content in the liver of mouse fed the brown seaweed lipids was higher than that of mouse fed control diet [2]. This suggested the involvement of fucoxanthin and/or polyphenols as major antioxidants in the brown seaweed lipids to the lower hydroperoxide levels in the liver. The major problem is their bioavailability and the difficulties in unraveling the complex mechanisms of absorp-
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
