Abstract
The study aimed to evaluate the in vitro properties of a new gel formulation (P-3086) as anti-aging treatment. Two in vitro methods aimed to assess and compare the efficacy of the gel formulation in reducing oxidative damages, artificially induced by UVA on skin-derived keratinocytes and in promoting the synthesis of collagen, compared with other four formulations. P-3086 reduced reactive oxygen species production after UVA stress with the highest effect observed at 0.016 mg/ml and 0.031 mg/ml concentration. P-3086 also promoted the collagen synthesis faster when compared with other formulations. The new gel product, based on hyaluronic acid, Vitamin E and Humulus lupulus, showed a good efficacy as anti-aging effect reducing the oxidative damages derived by the action of ROS, moreover stimulating the synthesis of one of the components of the connective tissue, the collagen.
Highlights
The desire for a long and healthy life is not an invention of modern times
We investigated the effectiveness of P-3086 to counteract oxidative damages, artificially induced by UVA on skin-derived keratinocytes, comparing the result with that of other formulations
The concentration of the actives in the different test products reflects those of P-3086, taking into account that the excipients content is unchanged in the different test products
Summary
The desire for a long and healthy life is not an invention of modern times. The dream of eternal youth has accompanied humans since ancient time and in all cultures: from the Byzantine Empress Zoe Porphyrogenita, that tried to keep her youth appearance until a prolonged age, applying on herself cosmetic essences and fragrances made in her personal laboratory in the imperial palace [1] to Indian traditional medicine and the ayurvedic perspectives on theories and management of aging [2]. All of them tried to seek a remedy to rejuvenation. The demand for an anti-aging therapy is higher day by day. People want to look younger because a youthful appearance reflects in a physical and mental health until very old age.
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