Abstract
Background and Aims: Macrophage migration inhibitory factor (MIF) has pleiotropic immune functions in a number of inflammatory diseases. Recent evidence from expression and functional studies has indicated that MIF is involved in various aspects of cardiovascular disease and autophagy. AMP-activated protein kinase (AMPK) plays role in maintaining cellular energy homeostasis. Previous studies showed that dysregulation of autophagy and decreased AMPK activity lead to atherosclerosis. In addition, it was shown that miR-18a is a regulator of autophagy and related with atherosclerosis associated genes. The aim of this study was to determine the expression of atherosclerosis related miR-18a and MIF gene and to test the dependence of their expression on AMPK activity in HUVEC.
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