Amoxicillin challenge without penicillin skin testing in evaluation of penicillin allergy in a cohort of Marine recruits

Abstract

Drug Allergy: Phenotypes, Endotypes, and BiomarkersThe Journal of Allergy and Clinical Immunology: In PracticeVol. 5Issue 3PreviewDrug allergy and hypersensitivity is a rising health care problem that affects all populations, adults and children, and represents one-third of visits to allergy clinics and more than 80% of inpatient consultations.1 The Food and Drug Administration approved 73 new drugs in 1995 and 118 in 2015, illustrating the increased pace of discovery and new treatments. This will bring several hundreds of new medications to the public in the next 10 years, and yet no tests are available to identify the populations at risk and to predict potential side effects. Full-Text PDF Moving Toward Optimizing Testing for Penicillin AllergyThe Journal of Allergy and Clinical Immunology: In PracticeVol. 5Issue 3PreviewAn unverified penicillin allergy is currently recognized as a significant public health risk.1 Penicillin allergy testing is now recommended as part of an effective antibiotic stewardship program.2 Millions of individuals currently need to have their penicillin allergies confirmed or removed from their medical records.3 Determining the safest and most cost-effective method(s) for confirming clinically significant IgE-mediated penicillin allergy or T-cell–mediated delayed-onset penicillin hypersensitivity is becoming increasingly important. Full-Text PDF