Abstract
Whether employed to search for nutrients or to rearrange tissues, cell migration is essential to the function of uni- and multicellular systems, both in healthy conditions and in disease. Among the several described modes of migration, amoeboid migration is particularly intriguing due to its apparent simplicity. Indeed, it requires only low levels of cell-substrate adhesion, which does not even have to be mediated by specific molecular bonds. This type of migration can be observed across a broad range of cell types including neutrophils, lymphocytes, and tumor cells, although the best-studied case is that of the amoeba of the lower eukaryote Dictyostelium discoideum.
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