Abstract
Background/Aim: Recently, a comparative study on the incidence of AFE has highlighted rather confusing results, showing that the complication is more than three times higher in North America than that in some European countries. In this paper, we put forward the hypothesis that this discrepancy is due to inaccurate diagnosis of non-classical form of AFE (atypical AFE). We also provide an outline of symptoms that characterize this type of AFE based on the analysis of all available case reports. Material and Methods: We searched Medline from 1969 (its inception) to 2011, using the key words “amniotic fluid embolism”. The search produced 1127 articles, including 208 case reports of AFE and other publications identified as eligible for our study (11 review articles and 6 population-based studies of the last few years). Moreover, we looked through the articles from the period before “inception of Medline” to find 178 earlier case reports. Full texts were analyzed. Results and Conclusions: (i) Worldwide, 447 cases of AFE have been reported, including 70 cases of atypical AFE (15.7%). (ii) Typical AFE is characterized by three clinical phases (cardiopulmonary collapse, clotting disorders and hemorrhages, multiorgan disturbances), whereas the atypical one shows lack of cardiopulmonary collapse as the initial presentation—the first to appear is obstetric hemorrhage and/or pulmonary and renal dysfunction. (iii) Four subclasses of atypical AFE were distinguished on the basis of case reports: uterine hemorrhage-type of AFE, ARDS as the only presentation of atypical AFE, paradoxical AFE, and cesarean section-related atypical AFEs.
Highlights
Amniotic fluid embolism (AFE) (Latin: embolia liquore amniotico) is a rare, yet an extremely dangerous perinatal complication, caused by invasion of the amniotic fluid to the maternal circulation
Results and Conclusions: (i) Worldwide, 447 cases of AFE have been reported, including 70 cases of atypical AFE (15.7%). (ii) Typical AFE is characterized by three clinical phases, whereas the atypical one shows lack of cardiopulmonary collapse as the initial presentation—the first to appear is obstetric hemorrhage and/or pulmonary and renal dysfunction. (iii) Four subclasses of atypical AFE were distinguished on the basis of case reports: uterine hemorrhage-type of AFE, ARDS as the only presentation of atypical AFE, paradoxical AFE, and cesarean sectionrelated atypical AFEs
This leads to life threatening complications, for both mother and child, such as cardiopulmonary collapse, often with cardiac arrest, hemorrhage with coagulopathy and multiorgan failure in mother, and effects of severe asphyxia in child
Summary
Amniotic fluid embolism (AFE) (Latin: embolia liquore amniotico) is a rare, yet an extremely dangerous perinatal complication, caused by invasion of the amniotic fluid to the maternal circulation This leads to life threatening complications, for both mother and child, such as cardiopulmonary collapse, often with cardiac arrest, hemorrhage with coagulopathy and multiorgan failure (adoult respiratory distress syndrome, ARDS, and others) in mother, and effects of severe asphyxia in child. The comparative study on the incidence of AFE has highlighted rather confusing results revealing that the complication is over three times more common in North America than that in some European countries [6,7] It is not clear whether all clinicians follow the same criteria to build up the diagnosis. We tried to consider the diagnostic aspects of literature data regarding the two forms of AFE, i.e. typical and atypical ones
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
