Abstract
Beta-2 microglobulin concentrations were measured in amniotic fluid obtained from 20 women at various stages of gestation. The concentrations averaged 6.3 μg per milliliter (range 5 to 10) between the tenth and thirty-sixth weeks and 0.87 μg per milliliter (range 0.2 to 1.3) after 36 weeks. This rapid third-trimester decrease in amniotic fluid concentration suggests that a major fetal pathway for metabolism of this protein becomes functional late in the course of gestation. From what is known of beta-2 microglobulin metabolism, this most likely relates to renal tubular function and suggests that this test may have significance in determining fetal age.
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