Abstract
The amnesic effects of the protein synthesis inhibitor cycloheximide were studied in two strains of mice ( C57BL 6J ; DBA 2J ) which have opposite temporal gradients of retention for single trial passive avoidance learning. Mice were given a single trial in a passive avoidance apparatus 30 min after a saline or a cycloheximide injection and tested for retention at seven intervals from 1 min to 72 hr following. Saline-injected C57BL 6J mice showed poor initial retention followed by progressive improvement which was sustained for 72 hr. In contrast, saline-injected DBA 2J mice showed good retention shortly after training followed by absence of retention 6 hr after training. A 3-mg dose of cycloheximide produced significant amnesia in both strains but the memory impairment was greater in the C57BL 6J strain when tested at 5 min. Increased early amnesia occurred when DBA 2J mice were given 5 mg of cycloheximide even though this dose did not significantly increase degree of protein synthesis inhibition. These results indicate that cyclohexamide can disrupt short-term as well as long-term memory and, in addition, raise the question whether the amnesic effect is due exclusively to inhibition of protein synthesis.
Published Version
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