Abstract
Therapeutic immunoadjuvants have been derived through a straightforward glycosylation of various alcohols with unprotected and non-activated monosaccharides, under solvent free conditions using ammonium chloride as a catalyst. Sugar acids such as glucuronic acid can be glycosylated without esterification and after acetylation yielded a novel 3,6-anhydro derivative. All the synthesized sugar glycosides were screened for immunomodulatory activities to be classified as immunostimulator, immunosuppressor, or immunoadjuvant against the weak antigen oval albumin (OVA). Most of the compounds revealed immunosuppressive (↓) or immunostimulatory (↑) activity with reference to lymphocyte proliferation and possess potential as vaccine adjuvants.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
