Abstract
Natural killer (NK) cells are a group of lymphocytes which destroy in vitro a variety of tumor cells in a nonselective way. The serum α-mannosidase activity was significantly higher in patients with liver cirrhosis (LC) than healthy subjects. α-mannosidase inhibited NK activity in vitro at low concentrations comparable to the serum level. NK activity was demonstrated to be directly proportional to serum ammonia level in patients with LC. These results suggest that α-mannosidase and ammonium are key factors determining NK activity in patients with LC.
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