Amlodipine-induced gingival hyperplasia

Abstract

Drug-induced gingival hyperplasia is the increased growth of gingival epithelium and submucosa which may cause bleeding and loss of teeth. Certain anticonvulsant, immunosuppressive, and antihypertensive drugs are the underlying cause in most cases. Among them, cases due to amlodipine are very rare. Here, we discuss the topic along with a case of gingival overgrowth induced by amlodipine. A 51-year-old female presented with gingival overgrowth. She was on amlodipine because of primary hypertension. She had gingival hyperplasia increasingly growing in the last few months. Her antihypertensive regimen was changed with cessation of amlodipine. This study suggests that amlodipine may lead to gingival hyperplasia.