Abstract
[Purpose]Sudden and exhaustive exercise causes muscle damage accompanied by oxidative stress and inflammation, leading to muscle fatigue and soreness. AmLexin contains a standardized blend of extracts from the heartwood of Acacia catechu and the root bark of Morus alba, and is known to possess antioxidant and anti-inflammatory properties. The aim of this study was to investigate the effects of this proprietary blend supplementation on muscular pain and redox balance in healthy runners, in comparison to a placebo.[Methods]A double-blind placebo-controlled clinical trial was carried out over 9 weeks in a single center. Thirty physically active male and female subjects within 18−70 years of age were randomized into AmLexin (mean age = 42.92 ± 2.48 and gender 7/5, male/female, respectively) and placebo (mean age = 41.15 ± 3.5 and gender 10/3, male/female, respectively) groups. Subjects were supplemented with 400 mg of AmLexin/day or a look-alike placebo during an 8-week training program, and for one week following a 13.1-mile half-marathon. Twenty-six subjects completed the 9-week supplementation trial.[Results]Results showed the AmLexin group experienced significantly lower levels of post-exercise pain on day 1−3 following the half-marathon compared to the placebo group. The AmLexin group also showed lower post-exercise oxidative stress and higher antioxidant capacity on days 1 and 6 following the half-marathon. These results demonstrated the rapid benefits of AmLexin on pain and oxidative stress within 1−6 days post-exercise.[Conclusion]Our data suggest that AmLexin could be a safe, effective botanical alternative for delayed onset muscle soreness.
Highlights
Individuals who are not accustomed to rigorous physical activity, or athletes who are returning to training from a prolonged period of inactivity, often experience a dull, aching pain that usually occurs within 24 hours after activity
When compared to subjects supplemented with the look-alike placebo, the improved comfort levels in the AmLexin group were statistically significant at days 1 (P < 0.05) and 3 (P < 0.03) (Fig. 2)
These reductions in magnitude were compared between the groups, and were found to be 43%, 40.5%, and 67.4% reductions for the AmLexin group on days 1, 2, and 3, respectively
Summary
Individuals who are not accustomed to rigorous physical activity, or athletes who are returning to training from a prolonged period of inactivity, often experience a dull, aching pain that usually occurs within 24 hours after activity This type of soreness is known as delayed onset muscle soreness (DOMS). These cells express cell surface adhesion molecules and release chemotactic factors and proinflammatory cytokines (e.g., IL-1β, TNF-α, IL-6)[8] These inflammatory mediators attract phagocytic cells such as neutrophils and monocytes toward the injury site. ROS may further lead to activation of NF-κB that can mediate the expression of inflammatory cytokines This may induce further inflammation and oxidative stress, leading to secondary muscle damage. In these orchestrated sequences of events, some factors seem to play important roles in
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