AML-242: Impact of Insurance Status and Distance from Residence to Treatment Center on the Outcomes of Patients Diagnosed with Acute Myeloid Leukemia

Abstract

<h3>Context:</h3> Numerous factors may affect the survival outcomes of patients with acute myeloid leukemia (AML), mainly disease-related and treatment-related factors. The impacts of other factors, such as the insurance status and the distance to healthcare facilities, are still unclear and may differ between different healthcare systems. <h3>Objective:</h3> The aim of this study is to investigate the effects of insurance status and distance to the treatment center on the survival of AML patients. <h3>Design:</h3> This is a single-center, observational, retrospective study of patients diagnosed with AML (2015–2020) and treated at the American University of Beirut Medical Center in Lebanon. <h3>Main Outcome Measures:</h3> Data regarding patient baseline characteristics, disease-related factors, insurance status, and area of residence were collected. Multivariate Cox regression analysis was used to identify main independent predictors of overall survival (OS). <h3>Results:</h3> We identified 142 AML patients with a median age of 52 years (range 18–86). Of them, 91 (64%) were males, 75 (53%) had ELN intermediate risk, and 88 (62%) patients received intensive chemotherapy. After a median follow-up of 22.4 months, the 2-year RFS and OS were 65% and 71%, respectively. The median RFS and OS were 63 months and not reached, respectively. A Cox regression model for OS was done using the following variables: age, gender, body mass index, ACE-27 comorbidity score, smoking status, insurance status, distance from the center, ELN classification, treatment used, and allotransplant. A higher risk of death was seen among the uninsured patients and those living beyond 40 km from the treatment center compared with fully insured patients and those living in proximity to the center (hazard ratio [HR]: 3.65; 95% CI [1.79, 7.45], p-value <0.0001; HR: 4.38; 95% CI [1.75, 10.95], p-value 0.002, respectively). <h3>Conclusions:</h3> The outcome of patients with AML does not depend only on disease-related factors, as the insurance status and the distance from the area of residence to the treatment center were found to be independent predictors of survival in AML patients.