Abstract
Context CD155 is called polio virus receptor (PVR) due to its function as the receptor for poliovirus; the role of CD 155 in hematological malignancies are limited. Objective The aim of the study is to measure CD 155 levels in serum of adult acute myeloid leukemia (AML) patients using (ELISA) and correlate the level with clinical outcome. Design Prospective study and follow-up for 6 months. Setting Clinical Hematology and Bone Marrow Transplantation Unit, Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt. Patients The study conducted on 30 randomly selected, newly diagnosed adult AML patients and 15 healthy controls of matched age and sex. Intervention Measurement of CD 155 levels in serum of adult AML patients and healthy controls using ELISA. Main outcome measures Measurement of CD 155 levels in serum of adult AML patients in comparison to healthy controls and correlate its level with clinical outcome. Results Serum CD 155 was significantly higher in AML patients in comparison to controls (mean=66.067 ± 30.172 ng/L vs 11.067 ± 5.021 ng/L, P Conclusion Adult AML patients have elevated CD 155 levels, which were associated with an inferior OS, DFS, and poor prognosis.
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