Abstract
Dose-dependent water exchange times and intracellular water contents were measured by NMR (nuclear magnetic resonance) in erythrocytes and mitochondria interacted with the anti-anginal and anti-arrhytmic agent, amiodarone. Addition of the drug up to 26 μM yielded 80% enhancement of the water exchange rate in erythrocytes at 37°C and 41% enhancement at 22°C with 40% and 9%, respectively, increases in the intracellular water content. Similar enhancements were obtained in mitochondria at 22°C. The data suggests a somewhat higher affinity of amiodarone to mitochondrial than to erythrocyte membranes.
Published Version
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