Abstract
Recent demonstration of the therapeutic efficacy of stilbamidine and 2-hy-droxystilbamidine in blastomycosis (1-9) has stimulated investigation of other diamidine derivatives as fungistatic agents. Hydroxy stilbamidine has been shown to have some suppressive influence on the course of coccidioidomycosis (10-12). Substitution of an amino for the hydroxy group results in a highly soluble orange crystalline compound, designated as aminostilbamidine. This newest stilbamidine derivative effectively inhibits the in vitro growth of C. immitis. The present study was directed toward establishing the in vitro spectrum of sensitivity of the important “systemic” fungi, evaluation of therapeutic efficacy in five patients with coccidioidomycosis, and observations of the human tissue concentration and distribution of aminostilbamidine.
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