Abstract
Abstract Reaction between 4-β-D-(O-acetyl)glycopyranosylaminopyrimidines 1 and chloracetylchloride yields the corresponding 5-α-chloracetyl derivatives 2, the hydrolysis products 3 and the corresponding 5-α-chloracetyl derivative of compounds 3. The former compounds were cyclized to the corresponding 7- β-D-glycopyranosyl-pyrrolo[2,3-d]pyrimidines 5 (2a yields 5,6-dihydro-4-β-D-(2,3,4,6-tetra-O-acetyl)glucopy-ranosylamino-2-methoxy-5-oxo-furo[2,3-d]pyrimidine 6a); the second ones to 3-β-D-(O-acetyl)glycopyranosyl-vic-triazolo[4,5-d] pyrimidines 10, and the last one to 4-β-D-(O-acetyl)glycopyranosylamino-furo[2,3-d] pyrimidines 7. The anticancer activity of some of these products is noticed.
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