Abstract
BB-K8 (1) is a new semisynthetic derivative of kanamycin acylated with L(-)-Υ-ammo-α-hydroxybutyric acid (L-HABA) at the C-l amino group of the 2-deoxystreptamine moiety. The chemistry1) and antimicrobial activity1, 2)) of BB-K8 have been reported. The present paper describes the two configurational isomers of BB-K8, which bear the DL- and D-HABA residue at the C-l amino group of kanamycin A, as well as the three positional isomers of BB-K8, which are acylated with L-HABA at the C-3, C-6' and C-3 amino groups of kanamycin A.
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