Abstract
AbstractAminodiazine, a sulfadiazine-ethylenediamine solid compound was prepared. This compound possesses a markedly higher aqueous solubility compared to sulfa-diazine. Equilibrium solubility and elemantal analysis data indicate a 1:1 molecular interaction. Investigation of the structure of aminodiazine in the solid state suggests strong association of the sulfonamido group of sulfadiazine with one of the basic groups of ethylenediamine probably through ionic and hydrogen bonding.From a practical standpoint, aminodiazine exhibits a much higher dissolution rate than sulfadiazine. In solution with a slight excess of ethylenediamine, aminodiazine proves compatible with four intravenous solutions over a study period of 8 hours. Further, the compound shows quantitatively the same antibacterial activity as sulfadiazine against test organisms.
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