Abstract
Aminodextran (AMD) coated magnetic cobalt ferrite nanoparticles are synthesized via electrostatic adsorption of aminodextran onto magnetic nanoparticles and their potential theranostic application is evaluated. The uncoated and aminodextran-coated nanoparticles are characterized to determine their hydrodynamic size, morphology, chemical composition, zeta potential and magnetization. The aminodextran containing cobalt ferrite nanoparticles of nanometer size are positively charged in the pH range from 3 to 9 and exhibit saturation magnetization of 50 emu/g. The magnetic resonance imaging (MRI) indicates capability for diagnostics and a reduction in intensity with an increase in nanoparticle amount. The hyperthermia capability of the prepared particles shows their potential to generate suitable local heat for therapeutic purposes. There is a rise of 7 °C and 9 °C at 327 kHz and 981 kHz respectively and specific absorption rates (SAR) of aminodextran-coated nanoparticles are calculated to be 259 W/g and 518 W/g at the given frequencies larger than uncoated nanoparticles (0.02 W/g). The development of novel aminodextran coated magnetic cobalt ferrite nanoparticles has significant potential to enable and improve personalized therapy regimens, targeted cancer therapies and ultimately to overcome the prevalence of nonessential and overdosing of healthy tissues and organs.
Highlights
To timely diagnose and treat cancer is among most the prevalent issues faced by biomedical research presently
Aminodextran-coated magnetic cobalt ferrite nanoparticles were prepared via the layer-by-layer assembly and, its potential application in magnetic resonance imaging (MRI) and hyperthermia were evaluated
Calcination of the precursor used for synthesis for 4 h at 400 ◦C is carried out to CoFe2O4 nanoparticles
Summary
To timely diagnose and treat cancer is among most the prevalent issues faced by biomedical research presently. For in vivo applications, the encapsulation of magnetic nanoparticles within a biocompatible polymer is essential [4,6], during or after the preparation process to prevent agglomeration [7] Due to their exceptional physical characteristics, hybrid magnetic nanoparticles can be applied as multifunctional materials, with the potential to be used in diagnosis and therapy, simultaneously [8]. The smaller the particle size and the higher the field intensity, the greater was the temperature rise that resulted in better heat induction in nanoparticles It is still quite interesting and challenging to improve and enhance the magnetic properties of nanoparticles to attain greater signal sensitivity for improved contrast in imaging and for increasing the heating efficacy in hyperthermia. Aminodextran-coated magnetic cobalt ferrite nanoparticles were prepared via the layer-by-layer assembly and, its potential application in MRI and hyperthermia were evaluated
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