Abstract
To the Editor.— We have recently observed the unusual association of amino-glutethimide administration with pregnancy. Amino-glutethimide is a potent inhibitor of steroid biosynthesis. It may soon be released for treatment of adrenocortical hyperfunction with excess cortisol or aldosterone secretion. The drug creates a partial block at the cholesterol desmolase reaction converting cholesterol to pregnenolone. Other blocks occur at the 21 and 11 hydroxylation reactions. 1,2 Genuine concern for potential side effects during gestation may be warranted in regard to the above effects, owing to this drug's relationship to thalidomide, another glutarimide. Also, the first block described is very similar to the complete defect seen in congenital lipoid adrenal hyperplasia, a fatal form with deficiencies of all steroids. Report of a Case.— A 22-year-old patient was referred for pregnancy termination at 27 weeks' gestation. A diagnosis of Cushing disease had been made elsewhere prior to conception, and she was treated with
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