Abstract
Sensitive and rapid detection of biomarker is an important but challenging task for diagnosis, treatment and monitoring of diseases. Herein, this study reports an amino-functionalized MOF-based fluorescent sensor (FJU-40-NH2), which is selectively and significantly quenched by 3-nitrotyrosine (3-NT), a key biomarker of kidney disease, featuring ultra-fast detection time (<15 s), high quenching efficiency, superior anti-interference capability and low detection limit (0.55 µM). More importantly, this fluorescent sensor is successfully employed for the determination of 3-NT in both healthy and acute kidney injury mice serums with recoveries of 96.3–103.3 %. The fluorescence quenching mechanism is attributed to the synergistic effect of the photoinduced electron transfer and internal filtration effect, as confirmed by UV–vis spectra and theoretical calculations.
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