Abstract

Chiral β-amino alcohols were used as ligands for ruthenium, rhodium and iridium-catalyzed asymmetric transfer hydrogenation of acetophenones in water with formate as reductant. The catalysts were showed to be capable of asymmetric transfer hydrogenation of ketones in water, but their activities and enantioselectivities varied with the ligands used and with solution pH values, with higher pH favouring higher rates and better enantioselectivities.

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