Abstract
Gold complexes have been traditionally employed in medicine, and currently, some gold(I) complexes, such as auranofin, are clinically used in the treatment of rheumatoid arthritis. In the last decades, both gold(I) and gold(III) complexes with different types of ligands have gained considerable attention as potential antitumor agents, showing superior activity both in vitro and in vivo to some of the clinically used agents. The present review article summarizes the results achieved in the field of synthesis and evaluation of gold complexes with amino acids and peptides moieties for their cytotoxicity. The first section provides an overview of the gold(I) complexes with amino acids and peptides, which have shown antiproliferative activity, while the second part is focused on the activity of gold(III) complexes with these ligands. A systematic summary of the results achieved in the field of gold(I/III) complexes with amino acids and peptides could contribute to the future development of metal complexes with these biocompatible ligands as promising antitumor agents.
Highlights
Gold and its compounds have been used for the treatment of a wide range of diseases throughout the history of civilization [1]
This gold(I) complex was found to be lethal to the microorganism, Mycobacterium tuberculosis, which is causative agent of tuberculosis [2]
The aim of this review is to present the findings obtained in the field of synthesis and evaluation of gold(I) and gold(III) complexes containing amino acids and peptides moieties for their antiproliferative potential
Summary
Gold and its compounds have been used for the treatment of a wide range of diseases throughout the history of civilization [1]. The mistaken belief that the Mycobacterium tuberculosis was a causative agent of rheumatoid arthritis led Landé and Forestier to use gold(I) thiolate complexes for the treatment of this disease [3]. After thirty years of medicinal debate, in 1960, British Empire Rheumatism Council confirmed the beneficial effects of the gold(I) thiolate complexes against rheumatoid arthritis [3]. Since that time, these complexes have been widely used in the treatment of a variety of rheumatic diseases including psoriatic arthritis, juvenile arthritis, palindromic rheumatism and discoid lupus erythematosus [3]. TTabalbele1. 1In. vInitrovictyrototcoyxtioctaocxtiicvitayct(iIvCi5t0y, 4(8ICh5,0μ, M48) ohf ,goμldM(I)) coofmgpolledx(eIs) wciotmh tphleexfeersrowceinthe btihoecofnejrurgoacteense 1–b6io[c1o9n].jugates 1–6 [19]
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