Abstract
Cardiotoxin(CTX)-analogue I was obtained in a yield of about 5.3% from the venom of naja naja atra by gel filtration on Sephadex G-50, followed by CM-cellulose column chromatography. When injected intraperitoneally in mice, its LD 50 was 2.8 (2.45–3.19) μg/g body weight. This toxin was cytotoxic to Yoshida sarcoma cells and produced contracture of the skeletal muscle as did CTX. The amino acid sequence of CTX-analogue I exhibits a high degree of homology with that of CTX from the same venom but differs in 13 positions.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
