Abstract
In a study on the genetic induction of melanoma in hybrids of poeciliidae the pattern of free amino acids was found richer and more acidic in tumour-disposed fish than in others. Changes in the amino acid level are accompanied by changes in the growth of the melanoma, independent of whether the amino acid change is determined by genetic constitution or by environmental conditions. All hybrids which produce melanomas have the high concentration of free amino acids before tumour formation; later it decreases, acidic amino acids dominating throughout (25–65% taurine). In a second free amino acid study on plants containing cancerostatic protein fractions an almost complementary pattern was found, the dominating compound being arginine (35%). The cancerostatic protein fraction is also basic. It is active only in the native state; inhibition may be compensated by DNA. In both studies an influence (one acting in the opposite direction to the other) on the attachment of histone to the nucleic acids is suggested.
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