Abstract
Amino Acid Functionalization of Multi-Walled Carbon Nanotubes for Enhanced Apatite Formation and Biocompatibility
Highlights
Carbon nanotubes (CNTs) have been used in different fields alone or as composites with other substances to develop highly functional materials
We demonstrated for the first time a novel approach based on the sol-gel technique for functionalization of multi-walled carbon nanotubes (MWCNTs) with two amino acids: L-arginine, L(+) Arg and L-aspargine, L(+) Asp
We have examined the effect of both functionalities on physicochemical properties of MWCNTs, cytotoxicity in osteosarcoma MG63 and normal fibroblastic BJ cells and the ability to induce nucleation and growth of hydroxyapatite (HA) crystals in vitro under physiological concentrations of Ca2+ and PO4+ (SBF)
Summary
Carbon nanotubes (CNTs) have been used in different fields alone or as composites with other substances to develop highly functional materials. They hold great promise as scaffolds for bone regeneration. Despite many surprising results obtained for CNTs from the beginning of this research field, there are still tremendous opportunities to be explored substantial questions and risks to be resolved. Vision and innovation are needed to elaborate changed conformation of CNTs and their conjugates with high effectiveness and safety for medicinal apply. Outstanding physical properties combined with a high aspect ratio and unique nanostructures make CNTs a potential candidate as reinforcement for many composites [1,2,3]. Three main problems need to be solved in order to make the http://www.nanobe.org
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